Firefighters in Guatemala say at least 19 children have died in a blaze at a care home about 25km (15 miles) south-east of the capital, Guatemala City.
About 20 other people were injured in the blaze at the Virgen de Asuncion home in San Jose Pinula.
It is not yet clear what caused the fire.
On Tuesday, police intervened after a riot broke out at the home. About 60 children escaped. Some allege they have been mistreated or sexually abused.
Local reports say the capacity of the home is 400, but that many more children were living there at the time.
The shelter takes in children up to the age of 18 who have suffered abuse or trafficking, or have been abandoned.